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VOLUME 1 , ISSUE 1 ( January-April, 2024 ) > List of Articles

REVIEW ARTICLE

Challenges of Salivary Metabolomics for Diagnosis of Metabolic Diseases

Masahiro Sugimoto, Shigeo Ishikawa, Chitta R Chowdhury

Keywords : Biomarker, Cancer, Metabolism, Metabolomics, Saliva

Citation Information : Sugimoto M, Ishikawa S, Chowdhury CR. Challenges of Salivary Metabolomics for Diagnosis of Metabolic Diseases. 2024; 1 (1):15-21.

DOI: 10.5005/bjotgh-11016-0001

License: CC BY-NC 4.0

Published Online: 30-04-2024

Copyright Statement:  Copyright © 2024; The Author(s).


Abstract

Saliva, a non-invasively and safely available biofluid, has been suited for diverse diagnostic tests. Recent investigations have explored its utility in assessing both oral conditions and systemic diseases. Metabolomics technologies enable simultaneous analysis of numerous metabolites and identify novel biomarkers to diagnose and predict therapeutic outcomes. Research on metabolomics-based salivary tests has been accumulated for disorders with metabolic dysregulation, such as periodontal disease and oral cancers. Clinical studies are also performed to develop and validate diagnostic markers of systematic cancers occurring in the organs far from the oral cavity. However, several challenges still exist in applying biomarkers in clinical settings. Establishing standardisation of processes, including saliva collection, storage, measurement, and data analysis, is imperative. Elucidating the rational mechanisms of molecular markers in saliva is essential. Here, we review the biological and technical aspects of the recent salivary tests.

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